Bone marrow mesenchymal stem cells alleviate the formation of pathological scars in rats.

ABSTRACT:

Introduction

Although bone marrow-derived mesenchymal stem cells (BMSCs) have attracted increasing attention because of their pivotal functions in the process of wound healing and fibrosis alleviation, the underlying molecular mechanisms have been poorly understood. Moreover, transforming growth factor beta 1 (TGF-β1) is positively correlated with scar formation, whereas TGF-β3 inhibits the pathological scar formation process. However, the relation of TGF-β1, TGF-β3, and the TGF-β/Smad signaling pathway with BMSCs is unknown and requires further investigation.

Methods

A cell co-culture platform was used to examine the relationship between BMSCs and dermal fibroblasts (DFs). EdU labelling and cell cycle detection were carried out to examine the viability of DF cells. Transwel

SUBMITTER: Xu JH 

PROVIDER: S-EPMC9048073 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature