Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy.

ABSTRACT: The limited clinical response and serious side effect have been challenging in cancer immunotherapy resulting from immunosuppressive tumor microenvironment (TME) and inferior drug targeting. Herein, an active targeting TME nanoplatform capable of revising the immunosuppressive TME microenvironment is designed. Briefly, gold nanorods (GNRs) are covered with silica dioxide (SiO₂) and then coated manganese dioxide (MnO₂) to obtain GNRs@SiO₂@MnO₂ (GSM). Myeloid-derived suppressor cells (MDSCs) membrane is further camouflaged on the surface of GSM to obtain GNRs@SiO₂@MnO₂@MDSCs (GSMM). In this system, GSMM inherits active targeting TME capacity of MDSCs. The localized surface plasmon resonance of GNRs is developed in near-infrare

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9048124 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature