Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy.

ABSTRACT:

Background

Integrase strand transfer inhibitor (InSTI)-based regimens have been recommended as first-line antiretroviral therapy (ART) for adults with HIV. But data on long-term effects of InSTI-based regimens on virologic outcomes remain limited. Here we examined whether InSTI improved long-term virologic outcomes compared with efavirenz (EFV).

Methods

We included adults from the North American AIDS Cohort Collaboration on Research and Design who initiated their first ART regimen containing either InSTI or EFV between 2009 and 2016. We estimated differences in the proportion virologically suppressed up to 7 years of follow-up in observational intention-to-treat and per-protocol analyses.

Results

Of 15 318 participants, 5519 (36%) initiated an InSTI-based regimen and

SUBMITTER: Lu H 

PROVIDER: S-EPMC9048218 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature