Evaluation of cytotoxic potential of structurally well-characterized RNA targeted ionic non-steroidal anti-inflammatory (NSAID) Cu(ii) & Zn(ii) DACH-mefenamato drug conjugates against human cancer cell lines.

ABSTRACT: New RNA targeted ionic [Cu(DACH)₂(H₂O)₂](mef)₂, 1 and [Zn(DACH)₂(H₂O)₂](mef)₂, 2 drug conjugates were synthesized and characterized by spectroscopic techniques FT-IR, UV-vis, EPR in case of 1 and ¹H and ¹³C NMR in case of 2, ESI-MS, thermogravimetric analysis and single-crystal X-ray structure determination in case of 1. The interaction studies of 1 & 2 with most likely drug targets like ctDNA and tRNA were performed which demonstrated that the complexes 1 and 2 exhibited strong preferential binding to tRNA as compared to ctDNA, K _b = 2.52(±0.04) × 10⁵ M^-1, 7.85(±0.02) × 10⁴ M^-1, respectively. Scanning electron microscop

SUBMITTER: Khan HY 

PROVIDER: S-EPMC9048248 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature