Biannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil.

ABSTRACT:

Introduction

Leptospirosis is a zoonosis with a worldwide spread that leads to clinical manifestations ranging from asymptomatic infection to a life-threatening disease. The immune response is predominantly humoral mediated limited to the infecting serovar. Individuals living in an area endemic for leptospirosis are often exposed to an environment contaminated with leptospires and there is a paucity of information on naturally acquired immunity. In the present study, we evaluated the kinetics of agglutinating antibodies in individuals from an endemic area for leptospirosis in Salvador, Brazil comparing two different intersample collection times.

Methods

Between 2017-2018, we carried out a biannual prospective cohort with 2,086 individuals living in an endemic area for leptos

SUBMITTER: Cruz JS 

PROVIDER: S-EPMC9048256 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature