Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology.

ABSTRACT: Circadian disruption is prevalent in Alzheimer's disease (AD) and may contribute to cognitive impairment, psychological symptoms, and neurodegeneration. This study aimed to evaluate the effects of environmental and genetic factors on the molecular clock and to establish a link between circadian rhythm disturbance and AD. We investigated the pathological effects of chronic sleep deprivation (CSD) in the APP^swe /PS1^ΔE9 transgenic mice and their wild-type (WT) littermates for 2 months and evaluated the expression levels of clock genes in the circadian rhythm-related nuclei. Our results showed that CSD impaired learning and memory, and further exaggerated disease progression in the AD mice. Furthermore, CSD caused abnormal expression of Bmal1, Clock, and Cry1 in the circa

SUBMITTER: Niu L 

PROVIDER: S-EPMC9048513 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature