Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) imposes a tremendous burden on human health, with high morbidity and mortality. Circular ribonucleic acids (circRNAs), a new type of noncoding RNA, are considered to participate in cancer pathogenesis as microRNA (miRNA) sponges. However, the dysregulation and biological functions of circRNAs in CRC remain to be explored.

Aim

To identify potential circRNA biomarkers of CRC and explore their functions in CRC carcinogenesis.

Methods

CircRNAs and miRNAs differentially expressed in CRC tissues were identified by analyzing expression profiles from the Gene Expression Omnibus (GEO) database. Circ_0000375 and circ_0011536 were selected as CRC biomarker candidates. Quantitative real-time polymerase chain reaction was utilized to evaluate the

SUBMITTER: Yin TF 

PROVIDER: S-EPMC9048569 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature