Bronsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source.

ABSTRACT: A Brønsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C-N bond and multi C-S bonds were selectively formed in one pot. The choice of the Brønsted acid was the key to the high efficiency of this transformation under metal-free conditions.

SUBMITTER: Ni P 

PROVIDER: S-EPMC9048575 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature