A Miniature Multilevel Structures for Lossless Ion Manipulations Ion Mobility Spectrometer with Wide Mobility Range Separation Capabilities.

ABSTRACT: Ion mobility spectrometry employing structures for lossless ion manipulations (SLIM-IMS) is an attractive gas-phase separation technique due to its ability to achieve unprecedented effective ion path lengths (>1 km) and IMS resolving powers in a small footprint. The emergence of multilevel SLIM technology, where ions are transferred between vertically stacked SLIM electrode surfaces, has subsequently allowed for ultralong single-pass path lengths (>40 m) to be achieved, enabling ultrahigh resolution IMS measurements to be performed over the entire mobility range in a single experiment. Here, we report on the development of a 1 m path length miniature SLIM module (miniSLIM) based on multilevel SLIM technology. Ion trajectory simulations were used to optimize SLIM board spacings and SLIM boa

SUBMITTER: Hollerbach AL 

PROVIDER: S-EPMC9048586 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature