Modelling of interactions between Aβ(25-35) peptide and phospholipid bilayers: effects of cholesterol and lipid saturation.

ABSTRACT: Aggregation of amyloid beta (Aβ) peptides in neuronal membranes is a known promoter of Alzheimer's disease. To gain insight into the molecular details of Aβ peptide aggregation and its effect on model neuronal membranes, we carried out molecular dynamics simulations of the Aβ(25-35) fragment of the amyloid precursor protein in phospholipid bilayers composed of either fully saturated or highly unsaturated lipids, in the presence or absence of cholesterol. It was found that the peptide does not penetrate through any of the considered membranes, but can reside in the headgroup region and upper part of the lipid tails showing a clear preference to a polyunsaturated cholesterol-free membrane. Due to the ordering and condensing effect upon addition of cholesterol, membranes become more rigid fac

SUBMITTER: Ermilova I 

PROVIDER: S-EPMC9048594 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature