Patterns of Translocation Testing in Patients Enrolling in a Cooperative Group Trial for Newly Diagnosed Metastatic Ewing Sarcoma.

ABSTRACT:

Context.—

Molecular diagnostics play an increasing role in the diagnosis of Ewing sarcoma. The type of molecular testing used in clinical practice has been poorly described.

Objective.—

To describe patterns of translocation testing for newly diagnosed Ewing sarcoma.

Design.—

Children's Oncology Group (COG) trial AEWS1221 was a phase III randomized trial enrolling patients with newly diagnosed metastatic Ewing sarcoma from 2014 to 2019. Patients were required to have a histologic diagnosis of Ewing sarcoma, but translocation testing was not required. Sites provided types and results of any molecular diagnostics performed.

Results.—

Data from 305 enrolled patients were available. The most common type of molecular testing was fluorescence in situ hybridization (FI

SUBMITTER: DuBois SG 

PROVIDER: S-EPMC9048754 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature