Pyrene-appended bipyridine hydrazone ligand as a turn-on sensor for Cu²⁺ and its bioimaging application.

ABSTRACT: A pyrene-appended bipyridine hydrazone-based ligand, HL, was synthesized and characterized by spectroscopic methods. Upon complexation with Cu(ii), HL formed a hexanuclear paddlewheel metal-organic macrocycle (MOM) via self-assembly with a high association constant with the molecular formula of [Cu₆L₆(NO₃)₆]. Intermolecular and intramolecular π-π interactions were demonstrated in this hexanuclear Cu(ii) complex. Further, it was observed that HL had the potential to detect a trace level of Cu(ii) ion selectively among a wide range of biologically relevant metal ions in aqueous medium at physiological pH. Using HL, it was feasible to sense copper(ii) ions in living cells due to its good cell permeability and high solubility under physiologic

SUBMITTER: Hossain SM 

PROVIDER: S-EPMC9048802 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature