Obesity in early adulthood and physical functioning in mid-life: Investigating the mediating role of c-reactive protein.

ABSTRACT:

Introduction

Obesity in adulthood is associated with reduced physical functioning (PF) at older ages. However, mechanisms underpinning this association are not well understood. We investigated whether and the extent to which C-reactive protein (CRP) mediates the association between early-adult obesity and mid-life PF.

Methods

We used data from 8495 participants in the 1958 British birth cohort study. Body mass index (BMI), CRP and PF were measured at 33, 45 and 50y, respectively. Poor PF was defined as the lowest (sex-specific) 10% on the Short-form 36 Physical Functioning subscale. We accounted for prospectively measured confounders in early-life (e.g., social class at birth) and in mid-adulthood (e.g., 42y comorbidities). We decomposed the total effect of early-adult obesi

SUBMITTER: Norris T 

PROVIDER: S-EPMC9048926 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature