PH-sensitive CAP/SiO₂ composite for efficient co-delivery of doxorubicin and siRNA to overcome multiple drug resistance.

ABSTRACT: Long-term administration of chemotherapeutic agents often leads to multiple drug resistance (MDR), which greatly impairs the treatment outcome. To overcome this problem, a biodegradable nanocarrier based on an acid-sensitive calcium phosphate/silica dioxide (CAP/SiO₂) composite was constructed for the codelivery of drug and siRNA. Anticancer drug doxorubicin (DOX) was encapsulated into the composite scaffold by interacting with the exposed Ca²⁺ of CAP/SiO₂ to achieve high drug loading (180 μg mg^-1). With further decoration of siRNA, the nanocarrier was applied to enhance the therapeutic efficacy by silencing MDR-relevant genes (P-gp) of DOX-resistance K562/ADR cancer cells. Benefiting from the intrinsic acid degradability of CAP/SiO₂,

SUBMITTER: Cai Z 

PROVIDER: S-EPMC9049068 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature