Finding a chink in the armor: Update, limitations, and challenges toward successful antivirals against flaviviruses.

ABSTRACT: Flaviviruses have caused large epidemics and ongoing outbreaks for centuries. They are now distributed in every continent infecting up to millions of people annually and may emerge to cause future epidemics. Some of the viruses from this group cause severe illnesses ranging from hemorrhagic to neurological manifestations. Despite decades of research, there are currently no approved antiviral drugs against flaviviruses, urging for new strategies and antiviral targets. In recent years, integrated omics data-based drug repurposing paired with novel drug validation methodologies and appropriate animal models has substantially aided in the discovery of new antiviral medicines. Here, we aim to review the latest progress in the development of both new and repurposed (i) direct-acting antivirals;

SUBMITTER: Komarasamy TV 

PROVIDER: S-EPMC9049358 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature