Influence of warm acupuncture on gut microbiota and metabolites in rats with insomnia induced by PCPA.

ABSTRACT:

Background

Insomnia is the most common of the sleep disorders. Current pharmacotherapy treatment options are usually associated with adverse effects and withdrawal phenomena. Therapeutic alternatives with a more favorable safety profile for patients are needed. Mongolian medical warm acupuncture (MMWA) is an emerging therapeutic option for treating insomnia. However, the underlying mechanisms responsible for the anti-insomnia efficacy of the MMWA remain unclear. This study aims to investigate the effect of the MMWA on the alterations of the gut microbiota and serum metabolome in rats with insomnia.

Results

We found that the relative abundances of gut bacteria and the concentrations of several serum metabolites were obviously altered in PCPA-induced insomnia rats. The MMWA tr

SUBMITTER: Yu H 

PROVIDER: S-EPMC9049555 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature