Direct use of 1,3-dienes for the allylation of ketones via catalytic hydroindation.

ABSTRACT: In this study, in situ catalytically generated allylic indium from 1,3 dienes and InCl₂H was developed for use in the allylation of ketones. This protocol resulted in the unprecedented establishment of a successive combining of quaternary C-C bonds, which could then be applied to many types of ketones. Other branched 1,3 dienes and vinyl cyclopropanes, could also be coupled with ketones in a reaction where CuH would not be applicable.

SUBMITTER: Suzuki I 

PROVIDER: S-EPMC9049578 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature