Immobilization of poly(lactide-co-glycolide) microspheres on bone implant materials for antibiotic release and the binding mechanisms.

ABSTRACT: Bone implants are susceptible to postoperative infections. Immobilization of antibiotic-loaded microparticles on implants is an effective approach to addressing this problem. Immobilization methods reported in earlier studies frequently used special or potentially harmful conditions. Therefore, the present study explored a new method to immobilize poly(lactide-co-glycolide) (PLGA) microspheres on bone implant materials. PLGA microspheres were prepared by an emulsion method using polyvinyl alcohol (PVA) as an emulsifier. The microspheres were immobilized on two commonly used orthopaedic biomaterials [hydroxyapatite-coated titanium (HA-Ti) and poly(methyl methacrylate) (PMMA)] by dispersing on the surface followed by vacuum drying. Microspheres were retained stably on both materials e

SUBMITTER: Wang D 

PROVIDER: S-EPMC9049854 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature