Assessing mortality differences across acute respiratory failure management strategies in Covid-19.

ABSTRACT:

Purpose

Prolonged observation could avoid invasive mechanical ventilation (IMV) and related risks in patients with Covid-19 acute respiratory failure (ARF) compared to initiating early IMV. We aimed to determine the association between ARF management strategy and in-hospital mortality.

Materials and methods

Patients in the Weill Cornell Covid-19 registry who developed ARF between March 5 - March 25, 2020 were exposed to an early IMV strategy; between March 26 - April 1, 2020 to an intermediate strategy; and after April 2 to prolonged observation. Cox proportional hazards regression was used to model in-hospital mortality and test an interaction between ARF management strategy and modified sequential organ failure assessment (mSOFA).

Results

Among 632 patients with ARF

SUBMITTER: Krishnan JK 

PROVIDER: S-EPMC9049881 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature