Self-assembly of glycerol monooleate with the antimicrobial peptide LL-37: a molecular dynamics study.

ABSTRACT: Over the past decade, the rapid increase in the incidence of antibiotic-resistant bacteria has promoted research towards alternative therapeutics such as antimicrobial peptides (AMPs), but their biodegradability limits their application. Encapsulation into nanocarriers based on the self-assembly of surfactant-like lipids is emerging as a promising strategy for the improvement of AMPs' stability and their protection against degradation when in biological media. An in-depth understanding of the interactions between the structure-forming lipids and AMPs is required for the design of nanocarriers. This in silico study, demonstrates the self-assembly of the amphiphilic lipid glycerol monooleate (GMO) with the antimicrobial peptide LL-37 into nanocarriers on the molecular scale. Molecular

SUBMITTER: Innocenti Malini R 

PROVIDER: S-EPMC9049931 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature