Screening and characterisation of CdTe/CdS quantum dot-binding peptides for material surface functionalisation.

ABSTRACT: Quantum dots (QDs) are promising nanomaterials due to their unique photophysical properties. For them to be useful in biological applications, the particle surface generally needs to be conjugated to biological molecules, such as antibodies. In this study, we screened CdTe/CdS QD-binding peptides from a phage display library as linkers for simple and bio-friendly QD modification. Among five QD-binding peptide candidates, a series of truncated peptides designed from two high-affinity peptides were subjected to an array-based binding assay with QDs to assess their functional core sequences and characteristics. Linking these isolated, shortened peptides (PWSLNR and SGVYK) with an antibody-binding peptide (NKFRGKYK) created dual-functional peptides that are capable of QD surface functionalisat

SUBMITTER: Suwatthanarak T 

PROVIDER: S-EPMC9049935 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature