Essential oil loaded pectin/chitosan nanoparticles preparation and optimization via Box-Behnken design against MCF-7 breast cancer cell lines.

ABSTRACT: In the continuous search for effective cancer treatments, we here report a novel anticancer nanoparticulate system composed of jasmine oil (JO), an essential oil with proven anticancer activity and pectin/chitosan composite nanoparticles (Pec/CS NPs) as encapsulating materials to overcome JO's solubility and sensitivity problems using a green ionotropic gelation method. Pec/CS/JO NPs were formulated using Box-Behnken design (BBD) to estimate the interactions and effects of studied formulation variables on particle size, zeta potential and encapsulation efficiency to develop an optimized Pec/CS nanoformulation. The nano-encapsulation system preserved the consistency of total phenolic contents in JO and amended its thermal stability by 1.64 fold. The antioxidant potency of JO was enhanced af

SUBMITTER: Attallah OA 

PROVIDER: S-EPMC9049973 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature