Novel non-mulberry silk fibroin nanoparticles with enhanced activity as potential candidate in nanocarrier mediated delivery system.

ABSTRACT: Silk fibroin (SF) is well known for its excellent biocompatible properties facilitating its application in the field of biomedical engineering through different biomaterial fabrications in the recent era. Here in this study, novel nanoparticles from non-mulberry SF of Antheraea assamensis were fabricated, characterized and evaluated for its applicability as nanocarrier. Fabricated nanoparticles were initially compared with prevailing SF nanoparticles from Bombyx mori. Fabricated A. assamensis silk fibroin nanoparticles (AA-SFNps) were found to be lesser in size (80-300 nm in diameter) than B. mori silk fibroin nanoparticles (BM-SFNps) (120-500 nm in diameter). When checked for stability, AA-SFNps were found to be more stable than BM-SFNps in biological media. FT

SUBMITTER: Baruah RR 

PROVIDER: S-EPMC9050130 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature