A Secure High-Order Gene Interaction Detecting Method for Infectious Diseases.

ABSTRACT: Infectious diseases pose a serious threat to human life, the Genome Wide Association Studies (GWAS) can analyze susceptibility genes of infectious diseases from the genetic level and carry out targeted prevention and treatment. The susceptibility genes for infectious diseases often act in combination with multiple susceptibility sites; therefore, high-order epistasis detection has become an important means. However, due to intensive computational burden and diversity of disease models, existing methods have drawbacks on low detection power, high computation cost, and preference for some types of disease models. Furthermore, these methods are exposed to repeated query and model inversion attacks in the process of iterative optimization, which may disclose Single Nucleotide Polymorphism (SNP

SUBMITTER: Wang H 

PROVIDER: S-EPMC9050263 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature