Time-updated anion gap and cardiovascular events in advanced chronic kidney disease: a cohort study.

ABSTRACT:

Background

Studies examining associations between metabolic acidosis and cardiovascular events in chronic kidney disease (CKD) have shown conflicting results and have not differentiated between normal anion gap (hyperchloremic) acidosis and high anion gap acidosis. We aimed to examine the impact of normal and high anion gap acidosis, separately, on the risk of cardiovascular events among patients with CKD.

Methods

This retrospective cohort study included 1168 patients with an estimated glomerular filtration rate (eGFR) of 10-60 mL/min/1.73 m² and available data on anion gap. We analyzed the association of time-updated high anion gap (anion gap ≥9.2) with the rate of cardiovascular events using marginal structural models (MSMs) to account for time-dependent confoun

SUBMITTER: Asahina Y 

PROVIDER: S-EPMC9050520 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature