Comparative analysis of tools to predict rapid progression in autosomal dominant polycystic kidney disease.

ABSTRACT:

Background

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease and shows a wide phenotype. Only patients with rapid progression (RP) are included in clinical trials or are approved to receive disease-modifying drugs. This study aims at comparing different available predictive tools in ADPKD with the Mayo classification (MC) identification of rapid progressors based on high total kidney volume (TKV) according to age.

Methods

A total of 164 ADPKD patients were recruited retrospectively from a single centre. The performance of diverse tools to identify RP defined as being in MC categories 1C-1E was assessed.

Results

A total of 118 patients were MC 1C-1E. The algorithm developed by the European Renal Association-European Dialysis

SUBMITTER: Naranjo J 

PROVIDER: S-EPMC9050526 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature