Normative brain mapping of interictal intracranial EEG to localize epileptogenic tissue.

ABSTRACT: The identification of abnormal electrographic activity is important in a wide range of neurological disorders, including epilepsy for localizing epileptogenic tissue. However, this identification may be challenging during non-seizure (interictal) periods, especially if abnormalities are subtle compared to the repertoire of possible healthy brain dynamics. Here, we investigate if such interictal abnormalities become more salient by quantitatively accounting for the range of healthy brain dynamics in a location-specific manner. To this end, we constructed a normative map of brain dynamics, in terms of relative band power, from interictal intracranial recordings from 234 participants (21 598 electrode contacts). We then compared interictal recordings from 62 patients with epilepsy to the norm

SUBMITTER: Taylor PN 

PROVIDER: S-EPMC9050535 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature