Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.

ABSTRACT: Idiopathic Parkinson's disease is characterized by a progressive loss of dopaminergic neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's disease research has mainly focused on nigral dopaminergic neurons, although recent studies suggest disease-related changes also in non-neuronal cells and in midbrain regions beyond the substantia nigra. While there is some evidence for glial involvement in Parkinson's disease, the molecular mechanisms remain poorly understood. The aim of this study was to characterize the contribution of all cell types of the midbrain to Parkinson's disease pathology by single-nuclei RNA sequencing and to assess the cell type-specific risk for Parkinson's disease using the latest genome-wide association study. We profiled >41 000 singl

SUBMITTER: Smajic S 

PROVIDER: S-EPMC9050543 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature