C5a receptor inhibitor avacopan in immunoglobulin A nephropathy-an open-label pilot study.

ABSTRACT:

Background

Improvement of proteinuria as a marker for disease activity is associated with a better renal outcome in immunoglobulin A nephropathy (IgAN). Complement is an effector pathway in IgA-mediated kidney injury. Avacopan, a selective C5a receptor inhibitor, has previously shown efficacy in anti-neutrophil cytoplasmic antibody-associated vasculitis. The aim of this study was to evaluate the safety and efficacy of avacopan in patients with IgAN with persistent proteinuria despite a maximally tolerated dose of renin-angiotensin-aldosterone system blockade. The efficacy evaluation was based on the change in proteinuria.

Methods

This open-label pilot trial enrolled adult patients with biopsy-proven IgAN, urinary protein:creatinine ratio (UPCR) >1 g/g creatinine and an estim

SUBMITTER: Bruchfeld A 

PROVIDER: S-EPMC9050557 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature