Central obesity is selectively associated with cerebral gray matter atrophy in 15,634 subjects in the UK Biobank.

ABSTRACT:

Background

Obesity is a risk factor for both cardiovascular disease and dementia, but the mechanisms underlying this association are not fully understood. We examined associations between obesity, including estimates of central obesity using different modalities, with brain gray matter (GM) volume in the UK Biobank, a large population-based cohort study.

Methods

To determine relationships between obesity and the brain we used brain MRI, abdominal MRI, dual-energy X-ray absorptiometry (DXA), and bioelectric whole-body impedance. We determined whether obesity was associated with any change in brain gray matter (GM) and white matter (WM) volumes, and brain network efficiency derived from the structural connectome (wiring of the brain) as determined from diffusion-tensor MRI tra

SUBMITTER: Pflanz CP 

PROVIDER: S-EPMC9050590 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature