Synthetic progress toward the marine natural product zamamiphidin A.

ABSTRACT: An asymmetric synthetic approach to the octahydrofuro[3,4-b]pyridine framework of marine natural product zamamiphidin A has been described. The key steps include an asymmetric Michael addition of (R)-N-tert-butanesulfinyl imidate with enamidomalonate to install the C10 stereocenter, an intramolecular alkoxide exchange/Michael addition/hydrogenation sequence to construct the bicyclic ring system.

SUBMITTER: Wang H 

PROVIDER: S-EPMC9050630 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature