DNA-based copy number analysis confirms genomic evolution of PDX models.

ABSTRACT: Genomic evolution of patient-derived xenografts (PDXs) may lead to their gradual divergence away of their tumors of origin. We previously reported the genomic evolution of the copy number (CN) landscapes of PDXs during their engraftment and passaging¹. However, whether PDX models are highly stable throughout passaging², or can evolve CNAs rapidly^1,3, remains controversial. Here, we reassess the genomic evolution of PDXs using DNA-based CN profiles. We find strong evidence for genomic evolution in the DNA-based PDX data: a median of ~10% of the genome is differentially altered between matched primary tumors (PTs) and PDXs across cohorts (range, 0% to 73% across all models). In 24% of the matched PT-PDX samples, over a quarter of the genome is differentially

SUBMITTER: Hoge ACH 

PROVIDER: S-EPMC9050710 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature