Dataset Information

Clinical and Nonclinical Disposition and In Vitro Drug-Drug Interaction Potential of Felcisetrag, a Highly Selective and Potent 5-HT₄ Receptor Agonist.

ABSTRACT:

Background and objective

Felcisetrag (previously TAK-954 or TD-8954) is a highly selective and potent 5-HT₄ receptor agonist in clinical development for prophylaxis and treatment of postoperative gastrointestinal dysfunction (POGD). The rat, dog, and human absorption, distribution, metabolism, and excretion (ADME) properties of felcisetrag were investigated.

Methods

The metabolism and victim and perpetrator drug interaction potentials towards cytochrome P450s (CYP) and transporters were determined using in vitro models. The excretion, metabolite profile, and pharmacokinetics were determined during unlabeled and radiolabeled ADME studies in rat and dog for comparison with human. Due to a low clinical dose (0.5 mg) and radioactivity (~ 1.5 μCi), a combination of liq

SUBMITTER: Pusalkar S

PROVIDER: S-EPMC9050781 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Dataset Information

Clinical and Nonclinical Disposition and In Vitro Drug-Drug Interaction Potential of Felcisetrag, a Highly Selective and Potent 5-HT₄ Receptor Agonist.

Background and objective

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Clinical and Nonclinical Disposition and In Vitro Drug-Drug Interaction Potential of Felcisetrag, a Highly Selective and Potent 5-HT4 Receptor Agonist.

Background and objective

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Clinical and Nonclinical Disposition and In Vitro Drug-Drug Interaction Potential of Felcisetrag, a Highly Selective and Potent 5-HT₄ Receptor Agonist.