Diastolic Dysfunction in Systemic Sclerosis: Risk Factors and Impact on Mortality.

ABSTRACT:

Objective

To determine the independent risk factors for diastolic dysfunction (DD) in patients with systemic sclerosis (SSc) and to evaluate the impact of DD on mortality.

Methods

SSc patients enrolled in the Johns Hopkins Scleroderma Center Cohort between November 1, 2006 and November 1, 2017 with ≥1 analyzable 2-dimensional (2-D) echocardiogram in our system were included (n = 806). DD risk factors and SSc disease characteristics were prospectively obtained, and the presence or absence of DD was determined using the most recent 2-D echocardiogram. Logistic regression models examined associations between clinical risk factors and DD, and Cox proportional hazards models were used to assess survival.

Results

DD was present in 18.6% of participants. The majority of part

SUBMITTER: Hinze AM 

PROVIDER: S-EPMC9050815 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature