An efficient approach to optimal experimental design for magnetic resonance fingerprinting with B-splines.

ABSTRACT:

Purpose

To introduce a computationally efficient approach to optimizing the data acquisition parameters of MR Fingerprinting experiments with the Cramér-Rao bound.

Methods

This paper presents a new approach to the optimal experimental design (OED) problem for MR Fingerprinting, which leverages an early observation that the optimized data acquisition parameters of MR Fingerprinting experiments are highly structured. Specifically, the proposed approach captures the desired structure by representing the sequences of data acquisition parameters with a special class of piecewise polynomials known as B-splines. This incorporates low-dimensional spline subspace constraints into the OED problem, which significantly reduces the search space of the problem, thereby improving the compu

SUBMITTER: Scope Crafts E 

PROVIDER: S-EPMC9050816 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature