Inhomogeneous magnetization transfer MRI of white matter structures in the hypomyelinated shiverer mouse brain.

ABSTRACT:

Purpose

Inhomogeneous magnetization transfer (ihMT) MRI is uniquely sensitive to myelin with lipids as a primary source of its contrast. In this study, we investigated whether ihMT can detect white matter structures in the hypomyelinated shiverer mouse brain, a model of dysmyelination.

Methods

Conventional MT and ihMT images were acquired from ex vivo Rag2^-/- control and shiverer mouse brains at 7T using previously reported optimized saturation parameters.

Results

ihMT ratio (ihMTR) maps revealed hypomyelinated corpus callosum in the shiverer mouse brain, whereas conventional MT ratio (MTR) maps showed no clear contrast. The ihMTR values of the corpus callosum in the shiverer mice were reduced by approximately 40% compared to controls, but remained signific

SUBMITTER: Lee CH 

PROVIDER: S-EPMC9050838 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature