Exenatide for weight-loss maintenance in adolescents with severe obesity: A randomized, placebo-controlled trial.

ABSTRACT:

Objective

This study sought to evaluate the effect of 52 weeks of exenatide extended release (XR) on the maintenance of meal replacement therapy (MRT)-induced BMI reduction in adolescents with severe obesity.

Methods

In this randomized, double-blind, placebo-controlled trial, 100 participants aged 12 to 18 years with BMI ≥ 1.2 × 95th percentile were enrolled in a short-term MRT run-in phase. Those who achieved ≥5% BMI reduction during the run-in were then randomized to 52 weeks of exenatide XR 2.0 mg or placebo weekly. Both groups also received lifestyle therapy. The prespecified primary end point was mean percent change in BMI from randomization (post run-in) to 52 weeks in the intention-to-treat population.

Results

A total of 100 participants were enrolled, and 66 (

SUBMITTER: Fox CK 

PROVIDER: S-EPMC9050846 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature