Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions.

ABSTRACT: Network control theory provides a framework by which neurophysiological dynamics of the brain can be modelled as a function of the structural connectome constructed from diffusion MRI. Average controllability describes the ability of a region to drive the brain to easy-to-reach neurophysiological states whilst modal controllability describes the ability of a region to drive the brain to difficult-to-reach states. In this study, we identify increases in mean average and modal controllability in children with drug-resistant epilepsy compared to healthy controls. Using simulations, we purport that these changes may be a result of increased thalamocortical connectivity. At the node level, we demonstrate decreased modal controllability in the thalamus and posterior cingulate regions. In those u

SUBMITTER: Chari A 

PROVIDER: S-EPMC9050895 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature