An in-line digestive cartridge increases enteral fat and vitamin absorption in a porcine model of short bowel syndrome.

ABSTRACT:

Background & aims

Short bowel syndrome (SBS) occurs after intestinal loss resulting in parenteral nutrition dependence and micronutrient deficiencies, which may lead to life-limiting complications. ALC-078 is a cartridge containing immobilized lipase that connects in-line with enteral feeding sets and digests fats in enteral nutrition (EN). In this study, we evaluate the efficacy of ALC-078 to improve fat and nutrient absorption in a porcine SBS model.

Methods

Fifteen male Yorkshire piglets were assessed. Animals were randomized to no intestinal resection (n = 5), 75% resection (n = 5), or 75% resection + ALC-078 (n = 5). After recovery, animals were treated for 14 days. Piglets received 60% of nutrition from continuous EN and 40% from chow. The degree of fat malabsorption w

SUBMITTER: Tsikis ST 

PROVIDER: S-EPMC9050916 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature