Inhibition of DYRK1a Enhances Cardiomyocyte Cycling After Myocardial Infarction.

ABSTRACT:

Background

DYRK1a (dual-specificity tyrosine phosphorylation-regulated kinase 1a) contributes to the control of cycling cells, including cardiomyocytes. However, the effects of inhibition of DYRK1a on cardiac function and cycling cardiomyocytes after myocardial infarction (MI) remain unknown.

Methods

We investigated the impacts of pharmacological inhibition and conditional genetic ablation of DYRK1a on endogenous cardiomyocyte cycling and left ventricular systolic function in ischemia-reperfusion (I/R) MI using αMHC-MerDreMer-Ki67p-RoxedCre::Rox-Lox-tdTomato-eGFP (RLTG) (denoted αDKRC::RLTG) and αMHC-Cre::Fucci2aR::DYRK1a^flox/flox mice.

Results

We observed that harmine, an inhibitor of DYRK1a, improved left ventricular ejection f

SUBMITTER: Young A 

PROVIDER: S-EPMC9050942 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature