Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche.

ABSTRACT: Tissue homeostasis often requires a properly placed niche to support stem cells. Morphogenetic processes that position a niche are just being described. For the Drosophila testis, we recently showed that pro-niche cells, specified at disparate positions during early gonadogenesis, must assemble into one collective at the anterior of the gonad. We now find that Slit and FGF signals emanating from adjacent visceral mesoderm regulate assembly. In response to signaling, niche cells express islet, which we find is also required for niche assembly. Without signaling, niche cells specified furthest from the anterior are unable to migrate, remaining dispersed. The function of such niches is severely disrupted, with niche cells evading cell cycle quiescence, compromised in their ability to signal t

SUBMITTER: Anllo L 

PROVIDER: S-EPMC9050945 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature