Anti-cancer Drugs Associated Atrial Fibrillation-An Analysis of Real-World Pharmacovigilance Data.

ABSTRACT:

Background

Several anti-cancer drugs have been linked to new onset atrial fibrillation (AF) but the true association of these drugs with AF is unknown. The FDA Adverse Event Reporting System (FAERS), a publicly available pharmacovigilance mechanism provided by the FDA, collects adverse event reports from the United States and other countries, thus providing real-world data.

Objectives

To identify anti-cancer drugs associated with AF using the FAERS database.

Methods

The FAERS database was searched for all drugs reporting AF as an adverse event (AE). The top 30 anti-cancer drugs reporting AF cases were shortlisted and analyzed. Proportional reporting ratio (PRR) was used to measure disproportionality in reporting of adverse events for these drugs.

Results

When a

SUBMITTER: Ahmad J 

PROVIDER: S-EPMC9051026 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature