Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography.

ABSTRACT: The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.

SUBMITTER: Mazzoccanti G 

PROVIDER: S-EPMC9051050 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature