Ontology highlight
ABSTRACT:
SUBMITTER: Pumroy RA
PROVIDER: S-EPMC9051106 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Pumroy Ruth A RA Protopopova Anna D AD Fricke Tabea C TC Lange Iris U IU Haug Ferdinand M FM Nguyen Phuong T PT Gallo Pamela N PN Sousa Bárbara B BB Bernardes Gonçalo J L GJL Yarov-Yarovoy Vladimir V Leffler Andreas A Moiseenkova-Bell Vera Y VY
Nature communications 20220428 1
Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological and pathophysiological processes, making it a promising drug target. Here we present cryo-electron microscopy (cryo-EM) structures of rat TRPV2 in lipid nanodiscs activated by 2-aminoethoxydiphenyl borate (2-APB) and propose a TRPV2-specific 2-ABP binding site at the interface of S5 of one monomer and the S4-S5 linker of the adjacent monomer. In silico docking and electrophysiological studies confirm the ...[more]