API ionic liquids: probing the effect of counterion structure on physical form and lipid solubility.

ABSTRACT: Lipid based formulations (LBFs) are extensively utilised as an enabling technology in drug delivery. The use of ionic liquids (ILs) or lipophilic salts (LS) in drug delivery has also garnered considerable interest due to unique solubility properties. Conversion of active pharmaceutical ingredients (API) to ILs by pairing with an appropriately lipophilic counterion has been shown to decrease melting point of the salt complex and improve solubility in LBFs. However, the relationship between the structure of the counterion, the physicochemical properties of the resulting salts and solubility in LBFs has not been systematically explored. This study investigates the relationship between alkyl sulfate counterion structure and melting temperature (T _m or T _g) i

SUBMITTER: Ford L 

PROVIDER: S-EPMC9051119 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature