Tissue-type plasminogen activator induces TNF-α-mediated preconditioning of the blood-brain barrier.

ABSTRACT: Ischemic tolerance is a phenomenon whereby transient exposure to a non-injurious preconditioning stimulus triggers resistance to a subsequent lethal ischemic insult. Despite the fact that not only neurons but also astrocytes and endothelial cells have a unique response to preconditioning stimuli, current research has been focused mostly on the effect of preconditioning on neuronal death. Thus, it is unclear if the blood-brain barrier (BBB) can be preconditioned independently of an effect on neuronal survival. The release of tissue-type plasminogen activator (tPA) from perivascular astrocytes in response to an ischemic insult increases the permeability of the BBB. In line with these observations, treatment with recombinant tPA increases the permeability of the BBB and genetic deficiency of

SUBMITTER: Diaz A 

PROVIDER: S-EPMC9051146 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature