Lower cerebral oxygen utilization is associated with Alzheimer's disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers.

ABSTRACT: Oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO₂) are markers of cerebral oxygen homeostasis and metabolism that may offer insights into abnormal changes in brain aging. The present study cross-sectionally related OEF and CMRO₂ to cognitive performance and structural neuroimaging variables among older adults (n = 246, 74 ± 7 years, 37% female) and tested whether apolipoprotein E (APOE)-ε4 status modified these associations. Main effects of OEF and CMRO₂ were null (p-values >0.06), and OEF interactions with APOE-ε4 status on cognitive and structural imaging outcomes were null (p-values >0.06). However, CMRO₂ interacted with APOE-ε4 status on language (p = 0.002), executive function (p = 0.03), visu

SUBMITTER: Robb WH 

PROVIDER: S-EPMC9051148 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature