Role of main RNA modifications in cancer: N⁶-methyladenosine, 5-methylcytosine, and pseudouridine.

ABSTRACT: Cancer is one of the major diseases threatening human life and health worldwide. Epigenetic modification refers to heritable changes in the genetic material without any changes in the nucleic acid sequence and results in heritable phenotypic changes. Epigenetic modifications regulate many biological processes, such as growth, aging, and various diseases, including cancer. With the advancement of next-generation sequencing technology, the role of RNA modifications in cancer progression has become increasingly prominent and is a hot spot in scientific research. This review studied several common RNA modifications, such as N⁶-methyladenosine, 5-methylcytosine, and pseudouridine. The deposition and roles of these modifications in coding and noncoding RNAs are summarized in detail. B

SUBMITTER: Xue C 

PROVIDER: S-EPMC9051163 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature