Clinical lesson learned from genetic analysis in patients prior to surgical repair of hypospadias.
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ABSTRACT:
SUBMITTER: Listyasari NA
PROVIDER: S-EPMC9051356 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Clinical lesson learned from genetic analysis in patients prior to surgical repair of hypospadias.
Listyasari Nurin A NA Robevska Gorjana G Ayers Katie L KL Tan Tiong Yang TY Sinclair Andrew H AH Faradz Sultana M H SMH
Asian journal of urology 20220301 2
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Project description:BackgroundMany parents continue to reject caudal block since they worry about a rare neurological consequence that may happen. A parenteral surrogate is sought because it can induce recovery with features such as local analgesia.ObjectivesTo compare the efficacy and safety of intravenous dexmedetomidine versus caudal and general anesthesia (GA) in children undergoing hypospadias surgery repair.MethodsA randomized prospective study was conducted on 135 pediatric patients scheduled for hypospadias repair surgery in the hospital affiliated to Tanta University. The participants were divided into a control group (Group C) receiving GA, a caudal group receiving caudal block after GA, and a dexmedetomidine group (Group D) receiving intravenous dexmedetomidine after GA. The postoperative modified objective pain score (MOPS), the total pethidine received in the first 24 h postoperatively, and complications were recorded.ResultsThe patients receiving GA required a significantly higher pethidine dose than the other two groups without a significant difference between caudal and dexmedetomidine. The patients receiving dexmedetomidine were extubated significantly later than patients in the other two groups. Regarding the MOPS score, there was a significant difference between Group C and the other two groups 30 minutes and one hour after operation regarding movements, posture, and agitation. Moreover, a significantly larger number of patients developed tachycardia in Group C compared to the other groups.ConclusionsWith the caudal block, the benefits of smooth emergency can be obtained by intravenous dexmedetomidine; however, it had less analgesic efficacy in the pediatric patients undergoing hypospadias repair surgery.
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