Vitamin K2 Enhances Fat Degradation to Improve the Survival of C. elegans.

ABSTRACT: The beneficial effects of vitamin K (VK) on various chronic age-related syndromes have generally been considered dependent on its antioxidant effects. However, due to the distinct bioavailability and biological activities of VKs, exactly which of these activities and by what mechanisms they might act still need to be elucidated. In this study, we found that VK2 can extend the lifespan of C. elegans and improve the resistance to pathogen infection, heat stress and H₂O₂-induced inner oxidative stress. Importantly, the roles of VK2 on aging and stress resistance were shown to be dependent on enhanced fat metabolism and not due to its antioxidant effects. Moreover, the genes related to fat metabolism that were up-regulated following VK2 treatment play key roles in

SUBMITTER: Qu Z 

PROVIDER: S-EPMC9051363 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature